Multifunctional Dendrimer Formation Using Thiolactone Chemistry

Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy.

Multifunctional cancer therapeutic nanodevices have been designed and synthesized using the poly(amidoamine) (PAMAM) dendrimer as a carrier. Partial acetylation of the generation 5 (G5) PAMAM dendrimer was utilized to neutralize a fraction of the primary amino groups, provide enhanced solubility of the dendrimer during the conjugation reaction of fluorescein isothiocyanate (FITC) (in dimethyl s...

Targeting and detecting cancer cells using spontaneously formed multifunctional dendrimer-stabilized gold nanoparticles.

We develop a facile approach to fabricating multifunctional dendrimer-stabilized gold nanoparticles (Au DSNPs) for cancer cell targeting and imaging. In this work, amine-terminated generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers pre-functionalized with folic acid (FA) and fluorescein isothiocyanate (FI) are complexed with Au(III) ions, followed by acetylation of the amine groups on the de...

Supramolecular Nanofiber Formation of Macrocyclic Dendrimer

Novel macrocyclic dendrimers (Scheme 2), having two cis-1,3,5-cyclohexanetricarboxamide (1) or 1,3,5-benzenetricarboxamide units (3) in their core, were synthesized, and their self-assembly behaviors were evaluated in solution. Infrared spectroscopy of cis-1,3,5-cyclohexanetricarboxamide cored dendrimer (1) in CHCl3 indicated that formation of strong hydrogen-bonding interactions is taking plac...

Recent advances in click chemistry applied to dendrimer synthesis.

Dendrimers are monodisperse polymers grown in a fractal manner from a central point. They are poised to become the cornerstone of nanoscale devices in several fields, ranging from biomedicine to light-harvesting. Technical difficulties in obtaining these molecules has slowed their transfer from academia to industry. In 2001, the arrival of the "click chemistry" concept gave the field a major bo...

A Multifunctional Theranostic Platform Based on Phthalocyanine-Loaded Dendrimer for Ovarian Cancer Treatment